It will be compulsory to wear face masks in shops and other indoor public spaces in Wales from Monday, in response to a spike in Coronavirus cases.
Indoor meetings of more than six people from an extended household will be illegal in Wales from Monday.
The rule will not apply to children aged 11 and under, and up to 30 people from different households will still be able to meet outside.
Mr Drakeford said: “Today for the first time we will go to a point where 20 people in 100,000 are suffering from coronavirus in Wales.
“That is the threshold we use for people to have to quarantine coming back into the UK.
“And having reached that today, we will be making the use of face coverings mandatory in shops and in closed public spaces in Wales.”