Officers investigating the collision would like to speak to anyone who was on A4810 between Magor Brewery and Europarks industrial estate between midnight and 12:30am on Friday 19 July.
Gwent Police are appealing for witnesses after receiving a report of a road traffic collision on A4810 near Magor at around 12.20am on Friday 19 July.
Officers attended, along with personnel from the Welsh Ambulance Service, following a collision between a Mercedes articulated lorry and a silver Kawasaki motorcycle.
Paramedics confirmed that the rider, a 27-year-old man, had died at the scene.
His next of kin have been informed.
Police are asking for anyone who may have witnessed the collision or any motorists with dashcam footage that were using A4810 near Magor at the time to contact them.
You can contact Police via the website, by calling 101 or direct messaging on social media, quoting 2400239698 with any details.
Alternatively, you can call Crimestoppers anonymously on 0800 555 111.
